Acetazolamide Therapy in Patients with Heart Failure: A Meta-Analysis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463174/#:~:text=Acetazolamide%20is%20a%20carbonic%20anhydrase,and%20safer%20than%20sulfanilamide%20diuretic.

Vericiguat is a direct stimulator of soluble guanylate cyclase enzyme, an important enzyme in vascular smooth muscle cells. Specifically, vericiguat will bind to the beta-subunit of the target site on the soluble guanylate cyclase enzyme.[7] Soluble guanylate cyclase enzymes catalyzes the formation of cyclic GMP upon interaction with nitric oxide to activate a number of downstream signaling cascade which can compensate for defects in this pathway and resulting losses in regulatory myocardial and vascular cellular processes due to cardiovascular complications. 
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