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🧬📢 Navbatdagi hamkorlikdagi ilmiy maqolamiz ACS Journal of Chemical Information and Modeling jurnalida chop etildi! (IF- 5.7)🎉
Ushbu tadqiqot Center for Advanced Technologies - CAT Ilg'or texnologiyalar markazi - ITM olimlari bilan olib borayotgan mustahkam hamkorligimiz samarasidir. Ayniqsa, Artyom Baev rahbarligidagi guruhdagi iqtidorli yosh tadqiqotchi Khondamir Rustamovning o‘rni beqiyos — u sun’iy intellekt asosidagi molekulyar modellashtirish bo‘yicha ajoyib natijalarga erishib kelmoqda! 🚀🧠
🔍 Inson organizmidagi eng muhim o‘smaga qarshi oqsillardan biri — p53 o'rganildi. Bu oqsil saratonlarning 50% dan ortig‘ida mutatsiyaga uchraydi.
AlphaFold3, molekulyar dinamikaga asoslangan simulyatsiyalar orqali p53 ning 148 ta missens mutatsiyasini chuqur tahlil qilingan.
🔑 Tadqiqotdan asosiy natijalar:
- Ba’zi mutatsiyalar (masalan, R248P, N239S) DNK bilan bog‘lanish qobiliyatini kamaytiradi,
- Boshqalari (C238Y, P278R) esa bog‘lanishni kuchaytiradi, lekin sistemani beqarorlashtiradi,
- Qiziqarli tomoni shundaki, E285A, M243T kabi mutatsiyalar zararli ta’sirni kamaytirish (rescue) xususiyatiga ega bo‘lishi mumkin.
Tadqiqotimiz AI va hisoblash usullari yordamida saraton bilan bog‘liq molekulyar mexanizmlarni chuqur tushunishga imkon beradi 💡💊
🙏 Ushbu muhim tadqiqotda ishtirok etishga taklif qilgan hamkorlarim Artyom va Khondamirga chuqur minnatdorchilik bildiraman.
🧪🌍
🔗 https://pubs.acs.org/doi/abs/10.1021/acs.jcim.5c00580
#ACS #p53 #Cancer #AI #AlphaFold #moleculardynamics #ProteinChallenge #DNA
Ushbu tadqiqot Center for Advanced Technologies - CAT Ilg'or texnologiyalar markazi - ITM olimlari bilan olib borayotgan mustahkam hamkorligimiz samarasidir. Ayniqsa, Artyom Baev rahbarligidagi guruhdagi iqtidorli yosh tadqiqotchi Khondamir Rustamovning o‘rni beqiyos — u sun’iy intellekt asosidagi molekulyar modellashtirish bo‘yicha ajoyib natijalarga erishib kelmoqda! 🚀🧠
🔍 Inson organizmidagi eng muhim o‘smaga qarshi oqsillardan biri — p53 o'rganildi. Bu oqsil saratonlarning 50% dan ortig‘ida mutatsiyaga uchraydi.
AlphaFold3, molekulyar dinamikaga asoslangan simulyatsiyalar orqali p53 ning 148 ta missens mutatsiyasini chuqur tahlil qilingan.
🔑 Tadqiqotdan asosiy natijalar:
- Ba’zi mutatsiyalar (masalan, R248P, N239S) DNK bilan bog‘lanish qobiliyatini kamaytiradi,
- Boshqalari (C238Y, P278R) esa bog‘lanishni kuchaytiradi, lekin sistemani beqarorlashtiradi,
- Qiziqarli tomoni shundaki, E285A, M243T kabi mutatsiyalar zararli ta’sirni kamaytirish (rescue) xususiyatiga ega bo‘lishi mumkin.
Tadqiqotimiz AI va hisoblash usullari yordamida saraton bilan bog‘liq molekulyar mexanizmlarni chuqur tushunishga imkon beradi 💡💊
🙏 Ushbu muhim tadqiqotda ishtirok etishga taklif qilgan hamkorlarim Artyom va Khondamirga chuqur minnatdorchilik bildiraman.
🧪🌍
🔗 https://pubs.acs.org/doi/abs/10.1021/acs.jcim.5c00580
#ACS #p53 #Cancer #AI #AlphaFold #moleculardynamics #ProteinChallenge #DNA
ACS Publications
Investigation of Structural Mechanisms Underlying p53 Dysfunction Caused by 148 Missense Mutations Using AlphaFold3 and Molecular…
Tumor protein p53 (TP53) is a crucial regulator of genomic integrity, frequently mutated in more than half of all human cancers. These mutations predominantly target the DNA-binding domain (DBD), impairing p53’s interaction with DNA and its tumor-suppressive…
[Uz]📢 Navbatdagi ilmiy maqolamiz Frontiers in Physics jurnalida chop etiladi! 📘🧠🎉
Ushbu tadqiqotda jamoamiz aʼzosi Dr. Tohir Akramov, magistrlar Muhriddin Maxkamov va Rasul Mashalov, shuningdek xalqaro hamkorlarimiz – Dr. Parthiban Marimuthu (Åbo Akademi Universiteti, Finlyandiya) va Dr. Aamir Shahzad (Pokiston, Faisalobod Davlat Universiteti) bilan birgalikda ish olib bordik. 🌍👨🔬
🔍 Nima oʻrganildi?
Ushbu tadqiqot Parkinson kasalligi bilan bogʻliq α-sinuklein oqsilining polimorf tuzilmasiga oksidlanish qanday ta’sir qilishini molekulyar darajada tahlil qildi.
🧬 Natijalar shuni ko‘rsatadiki, oksidlanish oqibatida ushbu oqsil tolalarining barqarorligi pasayadi, bu esa kasallik rivojlanishini oldini olishda muhim omil bo‘lishi mumkin.
🔬 Ushbu mexanizmlarni chuqur tushunish kelajakda davolash strategiyalarini ishlab chiqish uchun muhim asos bo‘lib xizmat qiladi.
🥳 Barcha hamkorlarga va ishtirokchilarga minnatdorchilik bildiraman – tabriklaymiz! 👏
[En] 📢 Our next research paper has been accepted for publication in Frontiers in Physics! 🎉📚
In this collaborative work, our team member Dr. Toxir Akramov, Master's students Mukhriddin Makhkamov and Mashalov Rasul, along with our international partners Dr. Parthiban Marimuthu from Åbo Akademi University (Finland) and Dr. Aamir Shahzad from Government College University Faisalabad (Pakistan), worked together to explore an important issue in neurodegenerative research. 🧠🧬
🧪 What’s it about?
This study reveals how oxidation affects the polymorphic structure of α-synuclein, a key protein involved in the progression of Parkinson’s disease. The findings provide molecular-level insights into how oxidative modifications influence fibril dynamics and may contribute to disease mechanisms.
🔬 A deeper understanding of these processes could pave the way for therapeutic strategies to prevent or reverse harmful α-synuclein aggregates in the brain. 🌟
Congratulations to everyone involved in this impactful study! 👏
https://www.frontiersin.org/journals/physics/articles/10.3389/fphy.2025.1591640/abstract
Ushbu tadqiqotda jamoamiz aʼzosi Dr. Tohir Akramov, magistrlar Muhriddin Maxkamov va Rasul Mashalov, shuningdek xalqaro hamkorlarimiz – Dr. Parthiban Marimuthu (Åbo Akademi Universiteti, Finlyandiya) va Dr. Aamir Shahzad (Pokiston, Faisalobod Davlat Universiteti) bilan birgalikda ish olib bordik. 🌍👨🔬
🔍 Nima oʻrganildi?
Ushbu tadqiqot Parkinson kasalligi bilan bogʻliq α-sinuklein oqsilining polimorf tuzilmasiga oksidlanish qanday ta’sir qilishini molekulyar darajada tahlil qildi.
🧬 Natijalar shuni ko‘rsatadiki, oksidlanish oqibatida ushbu oqsil tolalarining barqarorligi pasayadi, bu esa kasallik rivojlanishini oldini olishda muhim omil bo‘lishi mumkin.
🔬 Ushbu mexanizmlarni chuqur tushunish kelajakda davolash strategiyalarini ishlab chiqish uchun muhim asos bo‘lib xizmat qiladi.
🥳 Barcha hamkorlarga va ishtirokchilarga minnatdorchilik bildiraman – tabriklaymiz! 👏
[En] 📢 Our next research paper has been accepted for publication in Frontiers in Physics! 🎉📚
In this collaborative work, our team member Dr. Toxir Akramov, Master's students Mukhriddin Makhkamov and Mashalov Rasul, along with our international partners Dr. Parthiban Marimuthu from Åbo Akademi University (Finland) and Dr. Aamir Shahzad from Government College University Faisalabad (Pakistan), worked together to explore an important issue in neurodegenerative research. 🧠🧬
🧪 What’s it about?
This study reveals how oxidation affects the polymorphic structure of α-synuclein, a key protein involved in the progression of Parkinson’s disease. The findings provide molecular-level insights into how oxidative modifications influence fibril dynamics and may contribute to disease mechanisms.
🔬 A deeper understanding of these processes could pave the way for therapeutic strategies to prevent or reverse harmful α-synuclein aggregates in the brain. 🌟
Congratulations to everyone involved in this impactful study! 👏
https://www.frontiersin.org/journals/physics/articles/10.3389/fphy.2025.1591640/abstract
The Life Scientific - Dame Pratibha Gai on training atoms to do what we want - BBC Sounds
https://www.bbc.co.uk/sounds/play/m002db9w
https://www.bbc.co.uk/sounds/play/m002db9w
BBC
The Life Scientific - Dame Pratibha Gai on training atoms to do what we want - BBC Sounds
Pratibha Gai on her microscope that brought chemical reactions into sharp focus.
Smart tiny 'seeds' grow carbon nanotubes to cool down small devices
https://interestingengineering.com/innovation/billion-tiny-seeds-grow-carbon-nanotubes
https://interestingengineering.com/innovation/billion-tiny-seeds-grow-carbon-nanotubes
Interesting Engineering
Smart tiny 'seeds' grow carbon nanotubes to cool down small devices
The goal is to understand and control the formation of alumina-supported iron nanoparticles using a high-tech microscope and machine learning.
Scientists Confirm Anti-Aging Drug Appears to Prolong Life in Animals : ScienceAlert
https://www.sciencealert.com/scientists-confirm-anti-aging-drug-appears-to-prolong-life
https://www.sciencealert.com/scientists-confirm-anti-aging-drug-appears-to-prolong-life
ScienceAlert
Scientists Confirm Anti-Aging Drug Appears to Prolong Life in Animals
Encouraging early signs.
Google DeepMind Releases AlphaGenome: A Deep Learning Model that can more Comprehensively Predict the Impact of Single Variants or Mutations in DNA - MarkTechPost https://share.google/kIeFv6DaxByMt40JX
MarkTechPost
Google DeepMind Releases AlphaGenome: A Deep Learning Model that can more Comprehensively Predict the Impact of Single Variants…
Google DeepMind’s AlphaGenome predicts the functional impact of single DNA variants across modalities using deep learning