Correct Answer -C
Ans. is 'c' i.e., It does not cause alopecia
Vincristine belongs to the plant alkaloid group of anticancer
* Useful for inducing remission in childhood ALL (not useful in
maintenance therapy)
* It can also be used for pediatric solid tumors (Wilm's tumor,
neuroblastoma, rhabdomyosarcoma) and lymphomas
* Prominent adverse effects?
* Peripheral neuropathy
Alopecia
SIADH

Correct Answer - A
Ans. is 'a' i.e., Inhibits mitotic spindle
Vinca alkaloids (vincristine) inhibit mitotic spindles by preventing
polymerization of tubulin

Correct Answer - B
Ans. is `b ' i.e., Cisplatin
○ Cisplatin is the most common culprit causing chemotherapy
induced nausea and vomiting, therefore cisplatin is given as slow i.v.
infusion(never bolus) to prevent vomiting

Correct Answer-A
Ans. is 'a' i.e. Cisplatin
Some nephrotoxic_agents which_ cause tubular necrosis.
○ Aminoglycosides Colistin
○
Methoxyfluranes ○ Sulfonamides
○ Amphotericin B
o Cyclosporine
○
Polymyxin
○ Tetracyclines
○ Cephaloridine ○ Intravenous immune globulin
Radioiodinated contrast A cetaminophenmedium
○ Cisplatin

Correct Answer-D
Ans. is 'd' i.e., Aminoglycosides

Correct Answer A
Correct Answer- A
Ans. A. Plasma concentration
• In zero-order kinetics or saturation kinetics, elimination mechanisms
become saturated and unable to process more drugs when drug
concentrations rise
• Consequently, for drugs that are eliminated by zero-order
kinetics, a constant amount of drug is eliminated per unit time
regardless of drug plasma concentration.

Correct Answer - B
Ans. is 'b' i.e., Diarrhea
Cisapride is a prokinetic agent and often produces loose stools
(diarrhea is thus the commonest side effect)

Correct Answer -D
Propylthiouracil works primarily by inhibiting the peripheral conversion of T4 to T3.
The thyroid extracts iodide from the plasma and, in an oxidative process, iodinated tyrosine
residues in thyroglobulin molecules. Monoiodotyrosine and diiodotyrosine are formed and
then coupled to produce either thyroxine (tetraiodothyronine, T4) or triiodothyronine (T3).


Proteolytic cleavage of thyroglobulin molecules leads to free T3 or T4, which is then
released into the circulation; T3 is several times more potent than T4. Peripheral
deiodination of T4 at the 5' position leads to T3 formation (mainly in the liver); this step is
inhibited by propylthiouracil.


Decreasing the efficacy of TSH binding, decreasing the rate of thyroglobulin proteolysis,
increasing the amount of rT3 formation, and inhibiting the uptake of iodide into the thyroid.
would all tend to decrease the formation of thyroid hormones in the thyroid itself.

Correct Answer -C
Ans. is 'c' i.e., It does not cause alopecia
Vincristine belongs to the plant alkaloid group of anticancer
* Useful for inducing remission in childhood ALL (not useful in
maintenance therapy)
* It can also be used for pediatric solid tumors (Wilm's tumor,
neuroblastoma, rhabdomyosarcoma) and lymphomas
* Prominent adverse effects?
* Peripheral neuropathy
Alopecia
SIADH