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๐Ÿ’ Calcium Studies

โ—Serum Ca2+
โœงCauses of โ†‘
>10.2 mg/dL

โ†‘ Vit. D or Ca2+ intake. โ†‘ PTH. โ†‘ Bone breakdown. Hereditary disorders: e.g., Familial hypocalciuria. Metabolic: e.g., โ†‘โ†‘ Thyroid, acromegaly, Addison's. Drugs: e.g., Thiazides, Li+

โœงCauses of โ†“
<8.5 mg/dL

Vit. D/Ca2+ โ†“ intake / โ†“ absorption. โ†“ PTH or โ†‘ calcitonin Ca2+ sequestration: e.g., Saponification. โ†“ Albumin e.g., Liver disease. โ†“ Mg2+ or โ†‘ phosphorus (binds Ca2+) Osteoblastic malignancy. Drugs: e.g., Aminoglycosides .

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โ—Ionized Ca2+

โœงCauses of โ†‘
โ‡จ>5.3 mg/dL
Measures physiologically

โœงCauses of โ†“
โ‡จ<4.4 mg/dL
โ†“ with โ†‘ blood pH / โ†‘ protein

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โ‡นโ‡นโ‡นโ‡นโ‡นโ‡นโ‡นโ‡น

โ‡จpH 7.4
active nonbound Ca2+, โ†‘ with โ†“ blood pH or โ†“ protein or โ†“ albumin

โ‡จpH 7.4
โ†‘ albumin: e.g., Multiple myeloma, dehydration

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โ—Urine Ca2+ (UCa)
โœงCauses of โ†‘
โ†’>300 mg/24hr
โ†‘ serum Ca2+, also specific renal disease: e.g., Idiopathic hypercalciuria, RTA

โœงCauses of โ†“
โ†’<100 mg/24hr
โ†“ serum Ca2+, also specific renal disease and drugs: 
e.g., thiazides

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โ—Parathyroid hormone (PTH)
โœงCauses of โ†‘
>55 pg/mL
Primary / secondary โ†‘ Pparathyroid โ†“ Vit. D

โœงCauses of โ†“
<10 pg/mL
โ†“ Pparathyroid, โ†‘ thyroid, โ†“ Mg, โ†‘ nonparathyroid Ca2+

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โ—Vitamin D3 25-hydroxy [25(OH)D3]

โœงCauses of โ†‘
>50 ng/mL

โ†‘ Ca2+ โ†‘ Vit. D intake โ†‘ Sunlight exposure

โœงCauses of โ†“
<10 ng/mL

โ†“ Sunlight exposure, โ†“ Vit D intake / absorption . Pregnancy.
Drugs: phenobarbital, phenytoin.

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โ—Vitamin D3 1,25-hydroxy [1,25(OH)2D3]

โœงCauses of โ†‘
>76 ng/mL
โ†‘ Ca2+ โ†‘ Vit. D intake โ†‘ Sunlight exposure

โœงCauses of โ†“
<20 ng/mL
โ†“ Sunlight exposure,
โ†“ Vit D intake /absorption . 
Pregnancy. 
Drugs: phenobarbital, phenytoin.

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Clinical ๐Ÿ…ฑiochemistry
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๐Ÿ” Calcitonin Calcium (Ca2+) plays a significant role in both nervous conduction and muscle contraction.
It is also necessary for coagulation (clotting) of blood. The blood calcium level is regulated in part by calcitonin, a hormone secreted by the thyroid gland when the blood calcium level rises ๐Ÿ”

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Calcium Regulation
Hormonal Control of Blood Calcium Levels

Blood levels of calcium are regulated by the parathyroid hormone, which acts on the bones, kidneys, and intestines to keep levels constant.
๐Ÿ”บHYPERCALCEMIA & ๐Ÿ”ปHYPOCALCEMIA

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Clinical ๐Ÿ…ฑiochemistry
๐Ÿ”บHYPERCALCEMIA & ๐Ÿ”ปHYPOCALCEMIA @Biochem_Lab
๐Ÿ”
๐Ÿ”บHYPERCALCEMIA Hyperparathyroidism: usually an adenoma Malignancy: PTH-related peptide released by tumor (squamous cell, renal, breast, bladder) Vitamin D excess: granulomas (sarcoidosis, TB, Wegenerโ€™s) Increased bone turnover: hyperthyroidism, Pagetโ€™s
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๐Ÿ”ปHYPOCALCEMIA Hypoparathyroidism: sporadic, caused by thyroid surgery, Wilsonโ€™s, hypomagnesemia Vitamin D deficiency: no sunlight, GI disease Chronic renal failure: decreased 1,25(OH)D production, increased phosphate .

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๐Ÿ‘จโ€โš•Amount of hormones release in different occasionsโฃ

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๐Ÿ”ุชุนุฑู ุนู† ูƒู„ ู…ุง ูŠุชุนู„ู‚ ุจู…ุฑุถ ุงู„ุณูƒุฑูŠ ๐Ÿ”

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2025/06/28 09:55:43
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